Primordial germ cells (PGCs) are the foundational germline cells that eventually give rise to egg and sperm. Because PGCs carry physical materials transferred from one generation to the next, proper PGC development is crucial to individuals, to societies, and to species. Given this importance, PGCs are often set aside very early in embryogenesis, well before the testis or ovaries are formed, and must migrate through several tissues to reach the developing ovaries and testes. 

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